We are excited to share our latest study, in which we investigated how dynamic protein networks shape tissue formation during vertebrate development in collaboration with the Vermeulen lab. We adapted our previously published microfluidic system to synchronize oscillations in cultured mouse embryo tails and combined this with proteomics and RNA sequencing. This approach allowed us to map spatiotemporal […]
Author: Ina Sonnen
Ina has contributed to a recent publication in Development, titled “From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms”. This work provides a comprehensive framework for understanding how dynamical systems theory can elucidate the complex processes governing embryonic development. It underscores the importance of integrating quantitative models with experimental data […]
We are thrilled to announce that Ina Sonnen has been awarded tenure at the Hubrecht Institute! Since 2018, she has led groundbreaking research on dynamic signalling in development, tissue homeostasis, and disease. Read more about her journey and lab here.
We have contributed to a new study mainly run by the lab of Kim Dale published in Genes & Development, titled “NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids”. The work investigates how a mutation in NOTCH1, identified in T-cell acute lymphoblastic lymphoma […]
Ina and María J. Rodríguez-Colman have co-authored a new perspective in Cell Stem Cell titled “Signaling switches: Metabolism regulates gastruloid self-organization”. This article discusses how metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation plays a crucial role in regulating the self-organizing behavior of these […]
We have released a new preprint on bioRxiv exploring how cell proliferation is coordinated with the segmentation clock during embryonic development. Our results show that this coupling is essential for robust somitogenesis and accurate somite scaling. This work was a collaborative effort with Y. Irene Li and Ben Simons and provides new insights into the […]
Wilke and Ina have written a review, now published in Current Opinion in Systems Biology. In this article, we discuss how signalling gradients and oscillations regulate the periodic segmentation of vertebrate embryos, a process known as somitogenesis. We highlight recent advances and explore how the interplay between signalling dynamics and cellular mechanics drives somite formation. […]
We’re super excited to share that Yasmine el Azhar has successfully defended her PhD, becoming the first PhD graduate from the Sonnen Lab at the Hubrecht Institute! Yasmine’s work, titled “Notch signalling dynamics during mouse development and homeostasis,” gave us amazing new insights into how the Notch pathway controls embryonic development and tissue maintenance. She […]
We have published a new preprint on bioRxiv, revealing that the frequency of NOTCH-driven oscillations play a crucial role in regulating cell fate decisions during intestinal homeostasis. Their findings demonstrate that these oscillations are essential for maintaining the balance between stem cell maintenance and differentiation into absorptive and secretory lineages in the intestine. This research […]
In a recent preview article in Cell Stem Cell, Ina discusses a groundbreaking study by Liu et al. that introduces a microfluidic system capable of externally applying morphogen gradients to an in vitro model of human embryo segmentation. This innovative approach allows for precise control over gradient patterns, providing new insights into the mechanisms governing […]