Yasmine and Ina have written a short review about the different types of stem cell-based in vitro models of embryonic development. This includes embryo-like models such as blastoids and gastruloids as well as those models based on the directed differentiation of stem cells along specific trajectories, for instance the neural lineage. The publication can be […]
Together with Matthias Lutolf, Ananya Gupta and Alexa Hughes, Ina has written a review on bioengineering approaches in the establishment and optimization of embryo-like model systems. The review is part of a special issue on stem cell-based embryo-like model systems published in Stem Cell Reports. The publication can be found here. download pdf
Jan-Daniël has joined the group as PhD student. He will study signalling dynamics in the small intestine and the relevance of signalling dynamics in the context of tumorigenesis. Welcome!
We have been awarded a Unique High Risk Project grant funded by KWF and Alpes d’Huzes to study signalling dynamics in colorectal cancer. Pascal Schulthess will combine theory with experiments to understand how the timing of drug pulses influences the efficiency of chemotherapy
Marek and Wilke have described our microfluidic system for the functional investigation of signalling oscillations in developing mouse embryos in a Methods paper in JoVE.
We have been a awarded an NWO Klein-0 grant for the purchase of an inverted light-sheet microscope. It will be exciting to image embryonic tissues and adult tissue organoids at high spatiotemporal resolution. Have a look at the official announcement.
Today we had our first online joined lab meeting with the Garaycoecchea and Bothma labs. It also works via zoom …
Because of the Corona lockdown and working from home, we have taken the time to finally make a Sonnen Lab website.
Working from home
From today onwards, we have to work as much as possible from home. Only essential work can still be performed.
Our study on single-cell analysis of gastruloids got published, a very fruitful collaboration with the labs of Alfonso Martinez Arias and Alexander van Oudenaarden.